List of Famous people born in Castile-La Mancha, Spain

Álvaro de Luna y Jarana, 1st Duke of Trujillo, 1st Count of San Esteban de Gormaz, KOS, was a Spanish knight and politician. He was a favourite of King John II of Castile, a Constable of Castile and Grand Master of the military order of Santiago.

Manuel 'Manu' Trigueros Muñoz is a Spanish professional footballer who plays for Villarreal CF as a midfielder.

David Rodríguez Sánchez is a Spanish professional footballer who plays as a forward for Racing de Ferrol.

Juan Bravo was a leader of the rebel Comuneros in the Castilian Revolt of the Comuneros.

Sancho III, called the Desired, was King of Castile and Toledo for one year, from 1157 to 1158. He was the son of Alfonso VII of León and Castile and his wife Berengaria of Barcelona, and was succeeded by his son Alfonso VIII. His nickname was due to his position as the first child of his parents, born after eight years of childless marriage.

Elvira of Castile was a member of the House of Jiménez and the first queen of Sicily.

Víctor Mollejo Carpintero is a Spanish professional footballer who plays as a right winger for RCD Mallorca, on loan from Atlético Madrid.

Don Juan Manuel was a Spanish medieval writer, nephew of Alfonso X of Castile, son of Manuel of Castile and Beatrice of Savoy. He inherited from his father the great Seigneury of Villena, receiving the titles of Lord, Duke and lastly Prince of Villena. He married three times, choosing his wives for political and economic convenience, and worked to match his children with partners associated with royalty. Juan Manuel became one of the richest and most powerful men of his time, coining his own currency as the kings did. During his life, he was criticised for choosing literature as his vocation, an activity thought inferior for a nobleman of such prestige.

Rafael Martínez Carpena, known as Rafa Blas, is a Spanish rock and heavy metal-singer, mostly known as the winner of Spanish talent show La Voz in 2012. Before being a part of La Voz, he was the lead singer of melodic heavy metal band Matavys (2005–2010) and Toledo-based power metal-band Nocturnia (2010–2013).