List of Famous people born in Castile and León, Spain

Silvia Clemente Municio is a Spanish politician and civil servant. She is a member of the People's Party of Castile and León, and was the minister for the environment of the Junta of Castile and León from 2001 to 2003. She was appointed director general in charge of environmental quality on August 5, 1999. She was president of the Junta of Castile and León, from 2015 to 2019. She changed her obligation when she was appointed culture and tourism advisor in 2003. She was exercises the obligation of advisor to agriculture and livestock between 2007 and 2015. She announced her resignation as a member of the People's Party.

Ignacio Escolar García is a Spanish blogger and journalist. He currently leads the digital newspaper eldiario.es and he is also a political analyst in radio and television. He was founder and first director of the newspaper Público.

Mario Ramos is a Spanish actor, musician and poet.

Basilio Martín Patino was a Spanish film director, specializing in a creative approach to documentary works. Patino produced pieces on the Spanish Civil War, the famous dictator (Caudillo), or his executioners. He also produced fiction. Patino often experimented with new technologies, including digital tools, 3D, and offline editing.

Luis Garicano Gabilondo is a Spanish economist and politician who is currently a Member of the European Parliament (MEP) from Spain since 2019. He is also vice president of Renew Europe and vice president of the European political party Alliance of Liberals and Democrats for Europe. Before working in Brussels, he has been professor of strategy and economics at IE Business School in Madrid and at the London School of Economics (LSE).

Isacio Calleja García was a Spanish professional footballer who played as a defender.

Adolfo García-Sastre,(born in Burgos, 10 October 1964) is a Spanish professor of Medicine and Microbiology and co-director of the Global Health & Emerging Pathogens Institute at the Icahn School of Medicine at Mount Sinai in New York City. His research into the biology of influenza viruses has been at the forefront of medical advances in epidemiology.

Juan Yagüe y Blanco, 1st Marquis of San Leonardo de Yagüe was a Spanish military officer during the Spanish Civil War, one of the most important in the Nationalist side. He became known as the "Butcher of Badajoz" because he ordered thousands killed, including wounded men in the hospital.

Francisco Gómez de Sandoval y Rojas, 1st Duke of Lerma, 5th Marquess of Denia, 1st Count of Ampudia, was a favourite of Philip III of Spain, the first of the validos through whom the later Habsburg monarchs ruled. He was succeeded by the Count-Duke of Olivares.

Rubén Baraja Vegas is a Spanish retired footballer, and a current manager.