List of Famous people born in Antioquia Department, Colombia

Cristian David Echavarría Vélez is a Colombian professional footballer who plays for Independiente Medellín.

Alexis Zapata is a Colombian footballer who plays as a midfielder for C.S. Emelec.

Piedad Esneda Córdoba Ruiz is a Colombian lawyer and politician who served as Senator of Colombia from 1994 to 2010. A Liberal Party politician, she also served as Member of the Chamber of Representatives of Colombia for Antioquia from 1992 to 1994.

Julieth Restrepo is a Colombian model and actress.

Gildardo Biderman Gómez Monsálvez is a Colombian former footballer who played as defender specially in Atlético Nacional, where he won Copa Libertadores title, and Independiente Medellín. He was in the same generation from other good players in his position like León Villa and Luis Fernando Herrera. Gómez Monsálvez played 1990 FIFA World Cup in Italy.

Juan Camilo Restrepo Salazar was the 10th Minister of Agriculture and Rural Development of Colombia, serving in the administration of President Juan Manuel Santos Calderón. A veteran politician, he also served as the 63rd Minister of Finance and Public Credit of Colombia, the 17th Minister of Mines and Energy of Colombia, the 20th Ambassador of Colombia to France, and as Senator of Colombia. A lifelong member of the Conservative Party, he tried to run for the Conservative presidential nomination in 1998 and 2002, ultimately losing in the primaries both times.

Naty Botero is a Colombian model and singer. Born in Medellín, she moved to Bogotá at a young age and stayed there through high school. Botero studied in both Paris and New York City. Her first full-length album, Naty Botero, was released by Sony BMG in North America in early 2007. It contained the hit "Te Quiero Mucho". Three of Botero's other songs, "Fuego", "Dinosaurio," and "Mío" have appeared in the Colombian Top 40. In January 2007, El Tiempo chose her as that month's featured artist.

Julián David Arredondo Moreno is a Colombian former professional road cyclist, who rode professionally between 2012 and 2017 for the Trek–Segafredo and Nippo–Vini Fantini teams. Arredondo is best known for winning the mountains classification at the 2014 Giro d'Italia, as well as the 2012–13 UCI Asia Tour standings. He also competed at the 2014 Vuelta a España and the 2015 Tour de France.

José Tito Hernández Jaramillo is a Colombian road cyclist, who currently rides for UCI Continental team Medellín–EPM.

Jorge Aguirre is a Colombian footballer who plays as a forward for Categoría Primera A club Envigado.