List of Famous people born in Massachusetts, United States of America

Dmitri "Misha" Collins is an American actor, author, producer and director best known for his role as the angel Castiel on the CW television series Supernatural (2008–2020).

Rose Elizabeth Fitzgerald Kennedy was an American philanthropist, socialite, and a member of the Kennedy family. She was deeply embedded in the "lace curtain" Irish Catholic community in Boston, where her father John F. Fitzgerald was mayor. Kennedy was the wife of businessman and investor Joseph P. Kennedy Sr., who was United States Ambassador to the United Kingdom, formally known as Ambassador to the Court of St. James's in the UK. Their nine children included President John F. Kennedy, Senator Robert F. Kennedy, and longtime Senator Ted Kennedy. In 1951 she was ennobled by Pope Pius XII, becoming the sixth American woman to be granted the rank of Papal countess.

Mark Steven Fidrych, nicknamed "The Bird", was a Major League Baseball (MLB) pitcher. He pitched his entire career for the Detroit Tigers (1976–1980).

Wolf Martin Garber, known professionally as Bill Macy, was an American television, film and stage actor, best known for his role in the CBS television series Maude (1972–78).

Eleanor Torrey Powell was an American dancer and actress. Best remembered for her tap dance numbers in musical films in the 1930s and 1940s, Powell began studying ballet when she was six and was dancing at nightclubs in Atlantic City before she was a teenager. At the age of sixteen, she began studying tap and started appearing in musical revues on Broadway. She made her Hollywood debut as a featured dancer in the movie George White's Scandals (1935).

Rachel Susan Dratch is an American actress, comedian, and writer. Born and raised in Lexington, Massachusetts, she graduated from Dartmouth College in 1988 and moved to Chicago, Illinois, to study improvisational theatre at The Second City and ImprovOlympic.

Regina McCarthy is an American environmental health and air quality expert serving as the first White House National Climate Advisor under U.S. President Joe Biden. She served as the 13th Administrator of the Environmental Protection Agency (EPA) from 2013 to 2017.

Aron Steven Haddad is an American retired professional wrestler best known for wrestling with WWE under the ring name Damien Sandow. He is also known for his time in Total Nonstop Action Wrestling and the independent circuit under the ring name Aron Rex, where he was the first-ever Impact Grand Champion in 2016. He later appeared for the National Wrestling Alliance (NWA) before retiring from wrestling.

Peter Joseph Souza is an American photojournalist, the former Chief Official White House Photographer for Presidents of the United States Ronald Reagan and Barack Obama and the former director of the White House Photography Office. He was a photographer with The Chicago Tribune, stationed at the Washington, D.C., bureau from 1998 to 2007; during this period he also followed the rise of then-Senator Obama to the presidency.

Joseph Patrick Kennedy Jr. was a US Navy lieutenant who was killed in action during World War II while serving as a land-based patrol bomber pilot. He was posthumously awarded the Navy Cross and was the eldest of nine children born to Joseph P. Kennedy Sr. (1888–1969) and Rose Fitzgerald Kennedy (1890–1995).