List of Famous people born in Alcalá de Henares, Spain

Catherine of Aragon was Queen of England from June 1509 until May 1533 as the first wife of King Henry VIII; she was previously Princess of Wales as the wife of Henry's elder brother, Arthur.

Miguel de Cervantes Saavedra was a Spanish writer widely regarded as the greatest writer in the Spanish language, and one of the world's pre-eminent novelists. He is best known for his novel Don Quixote, a work often cited as both the first modern novel, and one of the pinnacles of literature.

José Ignacio Fernández Iglesias, known as Nacho, is a Spanish professional footballer who plays as a defender for Real Madrid and the Spain national team.

Pedro Mba Obiang Avomo is a Spanish-born Equatoguinean professional footballer who plays as a midfielder for Italian club Sassuolo and the Equatorial Guinea national team. He had previously played for Sampdoria, before moving to London, and the Premier League, in 2015. Obiang has represented Spain at under-17, under-19 and under-21 levels before switching to represent the Equatorial Guinea national football team.

Javier Calleja Revilla is a Spanish retired footballer who played mainly as a left midfielder, and a current manager.

Ferdinand I was Holy Roman Emperor from 1556, King of Bohemia, Hungary, and Croatia from 1526, and Archduke of Austria from 1521 until his death in 1564. Before his accession, he ruled the Austrian hereditary lands of the Habsburgs in the name of his elder brother, Charles V, Holy Roman Emperor. Also, he often served as Charles' representative in Germany and developed encouraging relationships with German princes.

Manuel Azaña Díaz was a Spanish politician who served as Prime Minister of the Second Spanish Republic, organizer of the Popular Front in 1935 and the last President of the Republic (1936–1939). He was the most prominent leader of the losing Republican cause during the Spanish Civil War of 1936-1939.

Cristóbal Gómez de Sandoval-Rojas y de la Cerda, known as the duque de Uceda, but also titled second marquis of Cea, fifth marquis of Denia, and knight of the order of Santiago was the official minister of state, also known as the valido or valued one, for King Philip III of Spain. He engineered the exile of his father the Duke of Lerma, from the court, and his own succession to the position.

Daniel Diges García is a Spanish singer, pianist, composer and actor. Although born in Madrid proper, he has spent all his youth in the neighbouring city of Alcalá de Henares.