List of Famous people born in Al Madinah Region, Saudi Arabia

Ali ibn Musa al-Rida, also known as Abū al-Ḥasan al-Thānī, was a descendant of the Islamic prophet Muhammad, and the eighth Imam in Twelver Shia Islam, succeeding his father, Musa al-Kazim. He is also part of the chain of mystical authority in Shia Sufi orders. He was known for his piety and learning, and a number of works are attributed to him, including Al-Risala al-Dhahabia, Sahifa al-Rida, and Fiqh al-Rida. Uyun al-Akhbar al-Rida by Ibn Babawayh is a comprehensive collection that includes the religious debates, sayings, biographical details, and even the miracles which have occurred at his tomb.

The Islamic figure Husayn ibn Ali had three daughters: Ruqayyah, Fāṭimah aṣ-Ṣughrā and Fāṭimah al-Kubrā.

Abu `Abdullah Muhammad Ibn ‘Omar Ibn Waqid al-Aslami was a historian commonly referred to as al-Waqidi. His surname is derived from his grandfather's name Waqid and thus he became famous as al-Imam al-Waqidi. Al-Waqidi was an early Muslim historian and biographer of the Islamic prophet Muhammad, specializing in his military campaigns. He served as a judge (qadi) for the Abbasid caliph al-Ma'mun. Several of al-Waqidi's works are known through his scribe and student, Ibn Sa'd.

Sa'd ibn Mu'adh (c.591-627) was the chief of the Aws tribe in Medina and one of the prominent companions of the Islamic prophet Muhammad. He died shortly after the Battle of the Trench.

Abu Ayyub al-Ansari — born Khalid bin Zayd bin Kulayb bin Thaalba in Yathrib — hailed from the tribe of Banu Najjar, was a close companion and the standard-bearer of the Islamic prophet Muhammad. Abu Ayyub was one of the Ansar of the early Islamic history, those who supported Muhammad after the hijra (migration) to Medina in 622. The patronym Abu Ayyub, means father (abu) of Ayyub. Abu Ayyub died of illness during the First Arab Siege of Constantinople.

Zayd ibn ʿAlī, also spelled Zaid, was the son of Ali ibn Husayn, and great-grandson of Ali. He led an unsuccessful revolt against the Umayyad Caliphate, in which he died. The event gave rise to the Zaidiyyah sect of Shia Islam, which holds him as the next Imam after Ali ibn Husayn. In contrast, his elder half-brother Muhammad al-Baqir is seen as the next Imam of the Twelver and Isma'ili Shias. Nevertheless, he is considered an important revolutionary figure by Shias and a martyr (shaheed) by all schools of Islam, Sunnis and Shias. The calling for revenge for his death, and for the brutal display of his body, contributed to the Abbasid Revolution.

Ruqayya bint al-Ḥusayn, was the daughter of Husayn ibn Ali and Rubab bint Imra al-Qais. Her brothers included Ali Zayn al-Abidin, Ali al-Akbar, and Ali al-Asghar. Her sisters included Fatima al-Sughra and Fatima al-Kubra, with the latter also being called 'Sakina'.

Muslim ibn Aaqil al-Hashimi was the son of Aqeel ibn Abi Talib and a member of the clan of Bani Hashim, thus, he is a cousin of Hussain ibn Ali. The people of Kufa called upon Husayn to overthrow the Umayyad dynasty who was on his way to Mecca for the Hajj pilgrimage. He wanted to confirm the loyalty of the people of Kufa, so he sent his cousin and his ambassador, Muslim ibn Aqeel, a famous warrior, to Kufa to observe the situation. He sent a letter to Hussain confirming their loyalty, before knowing that the 30,000 followers that he gained would all betray him for their lives. He was executed by the newly installed governor, Ubayd Allah ibn Ziyad, on the 9th of Zilhaj, 60 AH, and is buried at the back of Great Mosque of Kufa.

Ali al-Akbar ibn Al-Husayn, commonly known as simply Ali al-Akbar, was the son of Al-Husayn ibn Ali, the third Shia Imam, and Umm Layla. He was killed at the age of 18 on the day of Ashura, in the Battle of Karbala’. According to Jean Calmard writing in Iranica, ‘Ali al-Akbar's reputation as a valiant warrior of the Household of Muhammad might have preceded that of Al-‘Abbas ibn ‘Ali.

Fatimah bint Musa, commonly known as Fatimah al-Masumah was the daughter of the seventh Twelver Shia Imam, Musa al-Kadhim and sister of the eighth Twelver Shia Imams, Ali al-Rida. Every year, thousands of Shia Muslims travel to Qom to honor Fatima Masumeh at her shrine.